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Preheat oven to 350 degrees. Spray loaf pan with nonstick cooking spray.
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In a small bowl, whisk together egg, cream cheese, sugar, and flour until smooth. Set aside.
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To make the bread, combine flour, baking soda, spices, and salt and whisk together until combined.
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In the bowl of your mixer, combine pumpkin puree, sugars, and melted butter and beat until incorporated.
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Add eggs and vanilla and beat until smooth.
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Whisk in flour and milk and hand mix until just combined.
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Pour half of the batter into the pan.
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Carefully spread the cream cheese filling over batter in the pan.
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Pour the rest of the pumpkin bread batter over the cream cheese filling.
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Bake bread for 40-50 minutes or until a knife is inserted and comes out clean.
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Cool 10 minutes then invert to remove from pan.
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Sprinkle with powdered sugar before serving.