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Preheat oven to 350 degrees and line a loaf pan with parchment paper and spray with cooking spray.
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Bring all ingredients to room temperature.
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Mix all dry ingredients in the bowl of a mixer fitted with a paddle attachment.
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Combine the eggs, milk, orange zest and juice (milk will become more like buttermilk because of the orange zest), and vanilla extract in a separate bowl.
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Mix and set aside.
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Add butter and half of the egg mixture to the dry flour mixture.
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Beat until just combined (about 30 seconds).
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Scrape down the sides of the bowl and add the rest of the egg mix.
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Gently mix the entire batter with a wooden spoon.
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Stir in cranberries.
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Pour into pan and bake for 55 to 60 minutes at 350 degrees.
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To make the glaze, whisk together powdered sugar and orange juice until smooth.
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Pour over cooled cake.